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目的：评价中药白花前胡提取物（ＱＦ－８）降低慢性缺氧性肺动脉高压的急性疗效。方法：采用右心漂浮导管检测法观察口服ＱＦ－８对１１例慢性阻塞性肺疾病继发性肺动脉高压患者血流动力学和血气等的影响。结果：服药后３０ｍｉｎ时，肺动脉平均压、肺总阻力和肺血管阻力均明显下降，６０ｍｉｎ时分别下降１４％、２３％和３１％（Ｐ均＜０．０１），动脉血氧分压未见下降，氧运输量增加（Ｐ＜０．０５），体动脉压和体循环阻力等无变化。结论：ＱＦ－８有较好的选择性扩张肺血管、降低缺氧性肺动脉高压作用。
OBJECTIVE: To evaluate the acute effects of Chinese herbal medicine extract (QF-8) on chronic hypoxic pulmonary hypertension. METHODS: The right ventricle floating catheter assay was used to observe the effects of oral QF-8 on hemodynamics, blood gas, etc. in 11 patients with chronic obstructive pulmonary disease secondary to pulmonary hypertension. Results: At 30 minutes after taking the drugs, the mean pulmonary arterial pressure, total lung resistance, and pulmonary vascular resistance all decreased significantly. They decreased by 14%, 23%, and 31% at 60 minutes (P<0.01). No partial pressure of arterial oxygen was observed. Decreased, oxygen transport increased (P < 0.05), no change in body arterial pressure and systemic resistance. Conclusion: QF-8 has better selective expansion of pulmonary blood vessels and reduces hypoxic pulmonary hypertension.