目的 :建立 γ射线诱发小鼠恶性肿瘤动物模型。 方法 :BAL B/ c小鼠经 6 0 Coγ射线全身照射 ,每次吸收剂量 1.75Gy,吸收剂量率 0 .88Gy/ min,每周 1次 ,共 4次。照后每隔 1～ 2个月处死一批小鼠 ,分别取胸腺、肺脏、肝脏、脾脏、肾脏、胃、生殖腺、肠系膜、盲肠、大脑等组织器官 ,甲醛溶液固定后进行病理学检查及裸鼠致瘤实验。 结果 :照后 15个月 BAL B/ c小鼠出现的肿瘤类型以白血病为主 ,并发现汗腺瘤及恶性卵黄囊瘤 ;白血病经病理学证实为淋巴细胞型白血病 ;白血病及汗腺瘤的裸鼠致瘤实验已稳定连续传至第 12代。 结论 :成功建立 6 0 Coγ射线体外诱发的小鼠恶性肿瘤动物模型 Objective: To establish an animal model of malignant tumor induced by γ-rays in mice. METHODS: BALB / c mice were irradiated with 60Co γ-rays and absorbed 1.75 Gy each time. The absorbed dose rate was 0.88 Gy / min, once a week for 4 times. A group of mice were sacrificed every 1 to 2 months after irradiation. Tissues and organs such as thymus, lung, liver, spleen, kidney, stomach, gonad, mesentery, cecum, brain and brain were sacrificed and histopathology and naked Rat tumorigenicity experiment. Results: The tumor types of BAL B / c mice at 15 months after irradiation were leukemia and found to have sweat adenomas and malignant yolk sac tumors. Leukemias were pathologically confirmed to be lymphocytic leukemia; leukemias and sweat adenomas in nude mice Tumorigenicity experiments have been successfully passed on to the twelfth generation. Conclusion: The animal model of mouse malignant tumors induced by 60 Co γ-rays in vitro was successfully established