药物定量构-效关系(QSAR)的研究表明,药物的疏水性对于生物效应的贡献是重要的。药物的疏水性是药物易溶于大多数非极性溶剂而较难溶于水的性质。疏水性的大小是药物对多种生物膜穿透能力的量度;也是药物与疏水的蛋白质受体之间形成疏水键能力的量度。在QSAR 的有关文献中,作者等应用了各种色谱参数。其中有用R_M 等色谱参数来预示疏水性的大小;也有直接运用R_M 等色谱参数表示药物的疏水性,建立与生物活性的相关。本文讨论色谱参数R_M 值与疏水性的关 Quantitative structure-activity relationship (QSAR) studies have shown that the contribution of drug hydrophobicity to biological effects is important. Hydrophobicity of a drug is a property of a drug that is more soluble in most nonpolar solvents and less soluble in water. The size of the hydrophobicity is a measure of the drug’s ability to penetrate various biofilms; it is also a measure of the ability of the drug to bind hydrophobic protein receptors to form hydrophobic bonds. In the QSAR literature, the authors applied a variety of chromatographic parameters. Among them, R_M and other chromatographic parameters are used to predict the size of hydrophobicity. There is also a direct application of R_M and other chromatographic parameters to indicate the hydrophobicity of the drug and to establish the correlation with biological activity. This article discusses the relationship between chromatographic parameters R_M and hydrophobicity