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目的以宫颈活检组织病理学诊断为标准,对液基薄层细胞学检查宫颈癌及癌前病变的准确性进行评价,以提高和规范液基薄层细胞学检查的诊断水平。方法收集2006年5月到2007年12月期间在妇科门诊及住院就诊患者12,300例中288例宫颈脱落细胞学检查异常结果病例,采用新柏氏(Thinprep Cytology Test,TCT)操作系统提供的取样器取材,专用的液基保存液瓶保存标本,Thin-prep2000制片仪制片,巴氏染色。TCT筛查出ASCUS以上患者,均在阴道镜下行多点活检以作组织病理学检查。结果宫颈鳞状细胞癌诊断符合率为100%,高度病变符合率为93.1%,低度病变符合率为86.5%。结论液基薄层细胞学诊断宫颈癌及癌前病变(Cervical intraepithelial Lesion,CIN)具有较高的准确性,为宫颈病变的进一步诊断和治疗提供有效依据。
Objective To evaluate the accuracy of liquid-based thin-layer cytology in diagnosing cervical cancer and precancerous lesions based on histopathological diagnosis of cervical biopsy in order to improve and standardize the diagnostic level of liquid-based thin-layer cytology. Methods A total of 288 cases of cervical cytological abnormalities in 12,300 outpatients and inpatients from May 2006 to December 2007 were collected and sampled using a sampler provided by the ThinPrep Cytology Test (TCT) operating system , A dedicated liquid-based preservation of liquid bottles to save specimens, Thin-prep2000 film production system, Papa stain. TCT screening out more than ASCUS patients, multi-biopsy colposcope for histopathological examination. Results The coincidence rate of cervical squamous cell carcinoma was 100%, the coincidence rate of high grade lesions was 93.1% and the low grade lesion was 86.5%. Conclusions Liquid-based thin-layer cytology has a high accuracy in diagnosis of cervical cancer and precancerous lesions (Cervical intraepithelial lesion, CIN), which can provide an effective basis for the further diagnosis and treatment of cervical lesions.