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目的分析消化道息肉患者血清中性粒细胞明胶酶相关载脂蛋白(NGAL)的表达及其临床意义。方法对82例消化道息肉患者(息肉组)、30例消化道肿瘤患者(肿瘤组)和27例健康者(对照组)进行血清NGAL和癌胚抗原(CEA)检测。对检测结果进行对比分析。结果肿瘤组、息肉组、对照组血清NAGL浓度分别为(142.90±36.16)、(121.03±41.01)、(103.14±21.91)μg/ml,肿瘤组血清NAGL浓度高于息肉组及对照组,差异有统计学意义(P<0.05);息肉组血清NAGL浓度高于对照组,差异有统计学意义(P<0.05)。肿瘤组、息肉组、对照组血清CEA浓度分别为(12.39±25.54)、(2.45±1.45)、(2.32±1.79)ng/ml,肿瘤组血清CEA浓度明显高于息肉组及对照组,差异有统计学意义(P<0.05);息肉组及对照组血清CEA水平比较差异无统计学意义(P>0.05)。结论血清NGAL在消化道息肉、消化道肿瘤中表达逐渐升高,NGAL可能是筛查消化道癌前病变的潜在指标。
Objective To analyze the expression of serum neutrophil gelatinase-associated apolipoprotein (NGAL) in patients with gastrointestinal polyps and its clinical significance. Methods Serum NGAL and carcinoembryonic antigen (CEA) were detected in 82 patients with gastrointestinal polyp (polyp group), 30 patients with gastrointestinal cancer (tumor group) and 27 healthy controls (control group). The test results for comparative analysis. Results The serum concentrations of NAGL in tumor group, polyp group and control group were (142.90 ± 36.16), (121.03 ± 41.01) and (103.14 ± 21.91) μg / ml respectively. The serum NAGL concentrations in tumor group were higher than those in polyp group and control group (P <0.05). The concentration of NAGL in polyp group was higher than that in control group (P <0.05). The serum concentrations of CEA in tumor group, polyp group and control group were (12.39 ± 25.54), (2.45 ± 1.45) and (2.32 ± 1.79) ng / ml, respectively. The serum CEA concentration in tumor group was significantly higher than that in polyp group and control group (P <0.05). There was no significant difference in serum CEA levels between the polyp group and the control group (P> 0.05). Conclusion Serum NGAL is gradually increased in gastrointestinal polyps and digestive tract tumors, and NGAL may be a potential indicator for screening of precancerous lesions of digestive tract.