给豚鼠肌注抗生素８９－０７并用旋转试验评价前庭功能。２８天后用扫描电镜观察前庭壶腹嵴、椭园囊斑、球囊斑的形态改变，检测比较８９－０７与ＡＭＫ及ＧＭ对前庭器的影响，结果表明：８９－０７对前庭无明显损害，对前庭功能的影响与生理盐水组相比较没有显著差异，在大剂量时８９－０７虽对耳石膜有损害，并使感觉毛细胞的纤毛粘连，但８９－０７对前庭的毒性作用仍比庆大霉素及丁胺卡那霉素小得多。 Guinea pig intramuscular antibiotics 89-07 and use the rotation test evaluation of vestibular function. 28 days later, the morphological changes of vestibule ridges, oval plaques and balloon plaques were observed by scanning electron microscopy. The effects of 89-07 and AMK and GM on the vestibular structures were compared. The results showed that 89-07 had no significant damage to the vestibule, The effect on vestibular function was not significantly different from that of the saline group. Although 89-07 had a detrimental effect on the otoliths at high doses and sensitized the cilia of the hair cells, the toxic effects of 89-07 on the vestibule were still lower than those of 89-07 Gentamycin and amikacin much smaller.