论文部分内容阅读
用炔诺酮（５ｍｇｑ８ｈ×５天）抗早孕后作人工流产，对蜕膜和绒毛的超微结构进行观察。结果显示绝大部分蜕膜和绒毛滋养细胞均发生不同程度的退变和坏死。蜕膜组织中大蜕膜细胞和绒毛合体滋养细胞变性坏死较重，而蜕膜颗粒细胞和细胞滋养细胞仅轻度变性。细胞退变的超微结构特征皆以线粒体肿胀和粗面内质网扩张为先导，继之，线粒体固缩伴高电子密度颗粒沉积，内质网不规则扩张，直至细胞全面崩解。本文就炔诺酮通过引起子宫局部缺血而导致蜕膜和绒毛滋养层细胞变性坏死的可能性进行了讨论。
Ultrastructural changes of decidua and villi were observed with norethindrone (5 mgq 8h x 5 days) after induced abortion. The results showed that most of decidua and villous trophoblast cells have varying degrees of degeneration and necrosis. Decidual tissue decidual cells and villous syncytiotrophoblast degeneration and necrosis heavier, while decidual granulosa cells and cytotrophoblasts only mild degeneration. The ultrastructural features of cell degeneration are all caused by swelling of mitochondria and expansion of rough endoplasmic reticulum, followed by deposition of mitochondrial pyknosis with high electron density particles and irregular expansion of endoplasmic reticulum until the cells disintegrate completely. This article discusses the possibility that norethindrone causes degeneration and necrosis of decidual and villous trophoblast cells by causing uterine ischemia.