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水痘对免疫缺陷病人是一种危及生命的传染病。作者曾报导31例免疫缺陷患者用带状疱疹免疫血浆(ZIP)预防水痘的结果,本文系扩大60例的使用情况报告。这50名病人经诊断是:急性淋巴母细胞白血病(20例),其它恶性肿瘤(9例),肾移植(8例),胶原病(4例),使用免疫抑制剂者(9例)。其中有49例为5个月至13岁儿童,1例为40岁肾移植者。男女各25名。所使用ZIP为108单位(补体结合抗体效价为32～128,间接萤光试验测定效价为128～1024),于接触水痘后1～7天注射ZIP,剂量为3～14.3ml/kg。 50名病人注射ZIP后,7名发生临床水痘,1名(系暴露水痘感染后7天方注射ZIP者)发生严重水痘死亡,3名发生亚临床水痘,39名经临床及实验室证明均未发生水
Chickenpox is a life-threatening infectious disease to immunocompromised patients. The authors have reported 31 cases of immunodeficiency patients with herpes zoster immune serum (ZIP) to prevent the results of chickenpox, this article is to expand the use of 60 cases report. The 50 patients were diagnosed as acute lymphoblastic leukemia (n = 20), other malignancies (n = 9), renal transplant (n = 8), collagen disease (n = 4) and immunosuppressive agents (n = 9). Of these, 49 were children aged 5 months to 13 years and 1 was a 40-year-old kidney transplant. 25 for both men and women. The ZIP used was 108 units (complement-binding antibody titers 32-128, indirect fluorescent assay titers 128-124). ZIP was injected 1 to 7 days after exposure to chickenpox and the dose was 3-14.3 ml / kg. Serious chickenpox deaths occurred in 7 patients with clinically presented chickenpox and in 1 patient (ZIP injected with 7 days after exposure to chickenpox infection), subclinical chickenpox occurred in 3 patients, and none of the 39 patients were clinically and lab-certified water