硫氮(艹卓)酮(diltiazem hydrochloride,商品名:HERBESSER—90SR以下简称DZ)和硝苯地平(nifedipine)均为钙通道阻滞剂,其共同作用是通过阻滞钙通道,减少心肌和血管平滑肌组织激动时跨膜钙内流.但此作用具有选择性,它们在药物代谢动力学上亦有较大差别.故对心肌和体循环血管的影响并不相等.在治疗高血压病方面,硝苯地平报道较多,而有关90mg的DZ治疗高血压的经验有限.两者对高血压病人的作用和安全性的研究报道较少.本文就这两方面的问题进行两药的对比观察. Diltiazem hydrochloride (trade name: HERBESSER-90SR, hereinafter referred to as DZ) and nifedipine are calcium channel blockers that work together to block myocardial and vascular Smooth muscle excitability transmembrane calcium influx, but this effect is selective, they have significant differences in the pharmacokinetics, so the impact on myocardial and systemic blood vessels are not equal in the treatment of hypertension, nitrate There are more reports about benidipine, but there is limited experience about 90mg DZ in the treatment of hypertension, and there are few reports about the effects and safety of these two drugs on hypertensive patients.This paper compares the two drugs in these two aspects.