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目的:研究中医理论中的“鼻肺同治”以及对于龙脷平喘汤对于小儿哮喘气道炎症的作用机制以及作用的效果进行研究。方法:实验中以小白鼠作为实验对象,选取体重相近,健康的9只小白鼠进行实验,将小白鼠进行致敏和雾化激发从而进行痰癖证哮喘模型造模,之后分为三组,一组进行龙脷平喘汤治疗,一组进行地塞米松治疗,最后一组进行空白对照不作治疗。一段时间治疗之后对它们同时进行外血周EOS浓度、FasmRNA表达以及血清IL-4表达水平分析,同时对两组的治疗状况进行评级对比,从而验证龙脷平喘汤对于小儿哮喘气道炎症的作用效果和机理。结果:通过龙脷平喘汤的治疗,小白鼠的外血周EOS浓度降低,FasmRNA表达水平提高,血清IL-4表达水平下调,同时治疗效果相对地塞米松更为显著。结论:中医中的“鼻肺同治”是具有一定科学性的,并且论证了龙脷平喘汤的作用机理主要在于消除病变部位的炎症以及调整血液循环有关。
Objective: To study the theory of “nasal lung and lung cancer” in traditional Chinese medicine theory and its mechanism of action and effect on the airway inflammation of infantile asthma. Methods: In this experiment, mice were used as experimental subjects, 9 mice with similar body weight and healthy were selected for experiment. The mice were sensitized and atomized to induce asthma model of phlegm-induced asthma. The mice were divided into three groups Group Longsheng Pingchuan soup treatment, a group of dexamethasone treatment, the last group of blank control without treatment. After treatment for a period of time, they were simultaneously analyzed for peripheral blood EOS concentration, Fas mRNA expression, and serum IL-4 expression level, and compared the treatment status of the two groups to verify that Longji Pingchuan Decoction for airway inflammation in children with asthma Effect and mechanism. Results: Longdong Pingchuan Decoction treatment, mice peripheral blood EOS concentration decreased FasmRNA expression levels, serum IL-4 expression levels decreased, while the treatment effect is more significant than dexamethasone. Conclusion: The traditional Chinese medicine “nose and lungs with Tongzhi” is a scientific, and demonstrated that the main mechanism of action of Longji Pingchuan Decoction is to eliminate the inflammation of the lesion and to adjust the blood circulation.