乙酰水杨酸(ASA)是一种作用强烈、不可逆的血小板凝聚抑制剂,在体内经首过效应作用变成水杨酸(SA)后而失活。为了比较原形ASA在不同的ASA释药片剂中的生物利用度,作者检测健康受试者给予5种处方(即2种速释片即加有弱缓冲剂氧化镁的普通片和用碳酸-枸橼酸钠缓冲的泡腾片和3种缓解处方,即片剂中含微囊化ASA,胶囊中含微囊化ASA及包肠衣的ASA片)单个剂量后的血药浓度。由于用ASA Acetylsalicylic acid (ASA) is a potent and irreversible inhibitor of platelet aggregation that is inactivated by salicylic acid (SA) after a first-pass effect in the body. In order to compare the bioavailability of prototype ASA in different ASA release tablets, the authors tested healthy subjects for five prescriptions (ie, two immediate release tablets, plain tablets plus weak buffer magnesium oxide and a carbonated- Sodium citrate buffered effervescent tablets and three kinds of remission prescriptions, namely the tablet containing microencapsulated ASA, encapsulated microencapsulated ASA and enteric coated ASA tablets) after a single dose of plasma concentration. Thanks to ASA