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应用在位电生理技术研究了发育过程中的铅暴露对成年大白鼠海马齿状回超长时程增强(L-LTP)和双脉冲反应(PPF)的影响。结果表明,铅使海马神经元EPSP和PS诱导的L-LTP幅度降低,维持时间缩短,提示铅可能对形成长期记忆中起关键作用的新蛋白合成过程造成损伤。铅使双脉冲易化幅度降低,易化时间宽度变窄,提示铅主要使突触后NMDA受体造成损伤。
The effects of lead exposure during development on the long-term potentiation (L-LTP) and double-pulse response (PPF) of adult rat hippocampal dentate gyrus were studied using in situ electrophysiological techniques. The results showed that lead decreased the amplitude of L-LTP induced by EPSP and PS and decreased the maintenance time in hippocampal neurons, suggesting that lead might damage the synthesis of new proteins that play a key role in long-term memory. Lead to reduce the frequency of dual pulse facilitation, facilitation of narrowing the width of time, suggesting that lead mainly post-synaptic NMDA receptor damage.