背景他汀降低低密度脂蛋白胆固醇(LDL),预防血管事件,但它对低危者的净效应如何?仍不肯定。方法本荟萃分析包括22项他汀与对照比较的临床试验(134 537人,平均LDL差异1.08 mmol/L,随访中值4.8年)和5项比较较大剂量与较小剂量他汀的临床试验(39 612人,差异0.5l mmol/L;5.1年)。重大血管事件指重大冠心事件(即非致命性心肌梗死或冠心病死亡)、脑卒中或冠状动脉血运重建。这些临床试验的各自按基线对照者(不用他汀或很小量他汀)5 Background Statins reduce low density lipoprotein cholesterol (LDL) and prevent vascular events, but its net effect on low-risk people remains uncertain. Methods This meta-analysis included 22 clinical trials comparing statins to controls (134 537, mean LDL 1.08 mmol / L, median follow-up 4.8 years) and five more trials comparing larger and lower doses of statin 39 612 people, difference 0.5l mmol / L; 5.1 years). Major vascular events refer to major coronary events (ie death from non-fatal myocardial infarction or coronary heart disease), stroke, or coronary revascularization. Each of these clinical trials was controlled on a baseline basis (no statins or small amounts of statins) 5