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目的:观察NTIS在ICU重症患者中的发病情况,及对病情的预后。方法:2010年1月到2010年3月,收集上海交通大学附属第六人民医院重症监护病房ICU收治的患者共161例。根据甲状腺功能情况分组。记录其年龄、性别、血糖、血白蛋白、肝肾功能、电解质、白细胞、血气、心率、血压等,统计有创呼吸机的使用率、使用天数、APACHEII评分、ICU住院天数和住院期间的死亡率,分析相关的影响因素。结果:161例入住ICU的重症患者中74例伴有NTIS(45.96%),血清游离三碘甲状腺原氨酸(FT3)水平是ICU住院时间的独立影响因素,低T3与住院期间死亡率明显相关,是主要死亡危险因子;NTIS患者较正常甲状腺患者死亡风险增加2.93倍(95%CI,1.052～8.182)。结论:低T3在重症疾病患者中发病常见,与住院期间死亡率明显相关,对于预测患者病情的严重程度和预后有重要的价值。
Objective: To observe the incidence of NTIS in ICU critically ill patients and its prognosis. Methods: From January 2010 to March 2010, 161 patients admitted to ICU of the Sixth People’s Hospital Affiliated to Shanghai Jiaotong University were collected. According to thyroid function grouping. The age, sex, blood glucose, serum albumin, liver and kidney function, electrolytes, white blood cells, blood gas, heart rate, blood pressure and so on were recorded. The statistics of invasive ventilator usage, days of use, APACHEII score, ICU days of hospitalization and death during hospitalization Rate, analyze the relevant factors. Results: Seventy-four patients with severe ICU admitted to hospital were found to have NTIS (45.96%) and serum free triiodothyronine (FT3) levels were independent factors of ICU hospitalization. Low T3 was significantly associated with in-hospital mortality , Which is the major risk factor for death. The risk of death from NTIS patients was 2.93 times (95% CI, 1.052 to 8.182) higher than that of normal thyroid patients. Conclusions: Low T3 is common in patients with severe diseases and significantly related to in-hospital mortality, which is of great value in predicting the severity and prognosis of patients.