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目的:探讨米索前列醇不同途径给药终止10~16周妊娠的效果。方法:常规米非司酮50mg口服,1次/天,连服3d,于第4日加用米索前列醇。其给药方式分别为:口服组(单纯口服米索前列醇)、交替组(口服与阴道后穹窿置药交替进行)、观察组(口服的同时行阴道后穹窿置药各1片),每组各50例,观察三组流产及阴道出血情况。结果:观察组患者平均流产时间短,完全流产率高,阴道出血量少。差异比较具有统计学意义(P<0.05)。结论:米索前列醇口服与阴道后穹窿置药同时应用终止妊娠,疗效肯定,安全性高,值得临床推广。
Objective: To investigate the effect of different routes of administration of misoprostol for 10 to 16 weeks gestation. Methods: Conventional mifepristone 50mg orally, once daily, and even served 3d, on the 4th plus misoprostol. The administration groups were as follows: oral group (oral misoprostol alone), alternating group (oral and vaginal vault replacement medication alternately), observation group (oral vaginal fornix medication simultaneously) Group of 50 cases, observed three groups of miscarriage and vaginal bleeding. Results: The observation group patients with short average abortion, complete abortion rate, vaginal bleeding less. The differences were statistically significant (P <0.05). Conclusion: Misoprostol oral and vaginal fornix medication at the same time the application of termination of pregnancy, positive effect, high safety, worthy of clinical promotion.