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依林特肯（CPT-11）是喜树碱的半合成衍生物，育树碱和它的类似物／衍生物通过与拓扑异构酶1结合而发挥抗肿瘤作用。虽然喜树碱体外实验有效地抑制细胞生长，但该药在临床试验中毒副反应较大。构效研究的结果导致了一批疗效高，毒性低的喜树碱衍生物的发现。CFllll即是其中较有
Eplenticin (CPT-11) is a semisynthetic derivative of camptothecin, which exerts antitumor effects by binding to topoisomerase 1. Although camptothecin in vitro experiments effectively inhibit cell growth, but the drug toxicity in clinical trials side effects. The results of the structure-activity studies led to the discovery of a number of camptothecin derivatives with high efficacy and low toxicity. CFllll is one of them