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目的通过对近年来围产儿出生缺陷资料的搜集和分析,了解乌鲁木齐地区围产儿出生缺陷情况,为制定干预措施,降低出生缺陷发生率提供依据。方法对近8年乌鲁木齐地区出生缺陷发生情况进行回顾性分析。结果围产儿共212821例,出生缺陷儿1234例,发生率为58.35/万;男性围产儿出生缺陷率高于女性(χ2=4.65,P<0.05),城市围产儿出生缺陷率高于农村(χ2=107.98,P<0.01),产母年龄≥35岁组出生缺陷率高于产母年龄<35岁组(χ2=27.30,P<0.01),48.9%的出生缺陷儿在围产期的结局是死亡,62%的出生缺陷儿的孕母在孕早期患病、服药及接触过有害物质。结论加强健康教育,大力提倡婚前医学检查,做好流动孕产妇及高龄孕产妇的管理,提高产前筛查及产前诊断水平,降低出生缺陷的发生与出生,以提高出生人口素质。
Objective To understand the birth defects of perinatal infants in Urumqi by collecting and analyzing the data on birth defects in perinatals in recent years and provide basis for making interventions and reducing the incidence of birth defects. Methods The incidence of birth defects in Urumqi area in the past 8 years was retrospectively analyzed. Results There were 212821 perinatal infants and 1234 neonates with a birth rate of 58.35 per 100 000. The rate of birth defects in male perinatal children was higher than that in women (χ2 = 4.65, P <0.05). The rate of birth defects in urban perinatal children was higher than that in rural areas = 107.98, P <0.01). The birth defect rate of mother with birth age≥35 years was higher than that of mother with birth age <35 (χ2 = 27.30, P <0.01) Deaths, 62% of birth defects in pregnant women in early pregnancy sick, medication and exposure to harmful substances. Conclusions Strengthen health education, strongly advocate premarital medical examination, manage migrant and elder mothers well, increase the level of prenatal screening and prenatal diagnosis, and reduce the incidence and birth of birth defects in order to improve the quality of the birth population.