壁酸二肽(MDP)代表着福氏完全佐剂中完整分枝菌引起效应必需的最小活性结构。MDP及其一些佐剂活性衍生物能增强小鼠对感染的非特异抵抗力。一般认为,与细菌细胞壁有关的合成和天然醣肽的壁酸部分在免疫刺激活性中起重要作用。有些日本作者已描述一系列6,O—酰基—MDP衍生物,特别是用天然的棒状霉菌酸、如卡霉 Mural acid dipeptide (MDP) represents the minimum active structure necessary for complete mycobacterial elicitation in Freund’s complete adjuvant. MDP and some adjuvant active derivatives can enhance mice’s non-specific resistance to infection. It is generally believed that the wall acid moieties of synthetic and natural glycopeptides that are involved in bacterial cell walls play an important role in immunostimulatory activity. Some Japanese authors have described a series of derivatives of 6-O-acyl-MDP, in particular with natural corynidomycolic acids,