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目的探讨C-反应蛋白水平的变化在2型糖尿病患者中的临床意义。方法 2011年10月—2012年4月用免疫比浊法和己糖激酶法分别检测118例2型糖尿病患者和55名正常健康体检者的血清C-反应蛋白和空腹血糖水平,同时用Sysmex XT-1800i全自动五分类血细胞分析仪检测白细胞水平,并对各组检测结果进行对比分析。结果空腹血糖、C-反应蛋白和白细胞计数水平观察组分别为(8.50±1.18)mmol/L、(5.92±1.85)mg/L、(7.28±1.25)×109/L;对照组分别为:(4.95±0.54)mmol/L、(1.31±0.47)mg/L、(5.46±0.91)×109/L。两组比较差异均有统计学意义(均P﹤0.05)。结论 C-反应蛋白是发展为2型糖尿病的重要预测因子,可作为2型糖尿病的早期协助诊断指标之一,其与白细胞联合检测对2型糖尿病患者治疗效果的监测具有重要的临床意义。
Objective To investigate the clinical significance of the changes of C-reactive protein in type 2 diabetic patients. Methods The levels of serum C-reactive protein and fasting blood glucose in 118 type 2 diabetic patients and 55 normal healthy volunteers were detected by immunoturbidimetry and hexokinase assays from October 2011 to April 2012, respectively. Meanwhile, the levels of serum C-reactive protein and fasting plasma glucose were measured by Sysmex XT- 1800i automatic five-class blood cell analyzer to detect leukocyte levels, and test results for each group were compared. Results The levels of fasting plasma glucose, C-reactive protein and leukocyte count in the observation group were (8.50 ± 1.18) mmol / L, (5.92 ± 1.85) mg / L, (7.28 ± 1.25) × 109 / L, 4.95 ± 0.54) mmol / L, (1.31 ± 0.47) mg / L, (5.46 ± 0.91) × 109 / L, respectively. The differences between the two groups were statistically significant (P <0.05). Conclusion C-reactive protein is an important predictor for the development of type 2 diabetes mellitus, which can be used as an early diagnosis of type 2 diabetes mellitus. Combined with leukocyte detection, C-reactive protein has important clinical significance in the treatment of type 2 diabetes mellitus.