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作者对13例房室传导正常的病人用希氏束电图和心房起搏研究R011-1781(一种新的钙拮抗剂)的作用。方法:将两根电极导管经左股静脉插入右心部位,其中一根导管跨越三尖瓣以记录低位心房和希氏束电图。另一根四极导管置于右心房上部用于刺激心房和记录高位右心房电图。用多频道生理记录仪以100毫米/秒纸速同时记录体表导联Ⅰ、Ⅱ、Ⅲ、Ⅴ_1以及心脏内心电图,并用程序刺激仪刺激心房。心房起搏速率比自发的窦性速率稍快,然后以10次/分的速度增加起搏率,直至观察到房室结出现文氏
The authors studied the role of R011-1781, a novel calcium antagonist, in 13 patients with normal atrioventricular conduction using His bundle and atrial pacing. METHODS: Two lead catheters were inserted into the right heart through the left femoral vein. One of the catheters straddled the tricuspid valve to record the lower atrium and His bundle. Another quadrupole catheter was placed in the upper part of the right atrium to stimulate the atrium and record a high right atrial electrogram. The surface lead Ⅰ, Ⅱ, Ⅲ, Ⅴ_1 and heart electrocardiogram were recorded simultaneously with multi-channel physiology recorder at 100mm / s paper speed, and stimulated by program stimulator. The atrial pacing rate is slightly faster than the spontaneous sinus rate, and then increases the pacing rate at a rate of 10 beats / min until a ventricular node is observed