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目的通过观察2型糖尿病患者血清铁蛋白(SF)的变化及其影响因素,探讨血清铁蛋白与2型糖尿病的关系。方法测定60例2型糖尿病患者(糖尿病组)和30例健康体检者(对照组)的血清铁蛋白(SF)、空腹胰岛素(FINS)、空腹血糖(FPG)、血脂、糖化血红蛋白(HbA1c)的水平以及血压、体重、腰围、臀围,计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)。结果糖尿病组血清铁蛋白水平明显高于对照组(P<0.01),直线相关分析显示2型糖尿病患者SF与WHR呈正相关(P<0.05),与SBP、FPG、HbA1c、HOMA-IR呈显著正相关(P<0.01),与HDL-C呈负相关(P<0.05),与BMI、DBP、FINS、TC、TG、LDL-C无相关性(P>0.05)。结论2型糖尿病患者SF明显升高,提示铁蛋白代谢异常与2型糖尿病相关。
Objective To investigate the relationship between serum ferritin and type 2 diabetes by observing the changes of serum ferritin (SF) and its influencing factors in type 2 diabetic patients. Methods Serum ferritin (SF), fasting insulin (FINS), fasting blood glucose (FPG), lipids, HbA1c in 60 patients with type 2 diabetes mellitus (DM) and 30 healthy controls (control group) Level, blood pressure, weight, waist circumference, hip circumference, body mass index (BMI), WHR, HOMA-IR. Results The level of serum ferritin in diabetic group was significantly higher than that in control group (P <0.01). The linear correlation analysis showed that SF was positively correlated with WHR in type 2 diabetic patients (P <0.05), and positively correlated with SBP, FPG, HbA1c and HOMA-IR (P <0.01), but negatively correlated with HDL-C (P <0.05), but not with BMI, DBP, FINS, TC, TG and LDL-C. Conclusions SF in patients with type 2 diabetes mellitus is significantly elevated, suggesting that the abnormal ferritin metabolism is associated with type 2 diabetes mellitus.