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目的:观察舍曲林联合阿米替林治疗糖尿病周围神经病变的疗效。方法:选取麻园社区卫生服务中心2015年11月至2017年3月共30例糖尿病周围神经病变患者作为研究对象,以随机分配为原则,分为观察组和对照组各15例。对照组采用阿米替林进行治疗,观察组采用舍曲林联合阿米替林进行治疗,对比两组患者的临床疗效。结果:观察组患者汉密顿抑郁量表(HAMD)评分、数字疼痛评分法(NPRS)评分低于对照组患者,差异具有统计学意义(P<0.05);观察组患者总有效率高于对照组患者,差异具有统计学意义(P<0.05);观察组患者疼痛缓解时间、疼痛消失时间均优于对照组患者,差异具有统计学意义(P<0.05)。结论:舍曲林联合阿米替林治疗糖尿病周围神经病变具有良好的临床疗效,不仅可以有效缓解患者的抑郁情况,同时也可能缓解患者疼痛程度。
Objective: To observe the efficacy of sertraline combined with amitriptyline in the treatment of diabetic peripheral neuropathy. Methods: 30 patients with diabetic peripheral neuropathy from November 2015 to March 2017 in Ma Yuan Community Health Service Center were chosen as research objects. Randomly allocated as the principle, 15 patients were divided into observation group and control group. The control group was treated with amitriptyline. The observation group was treated with sertraline combined with amitriptyline, and the clinical efficacy was compared between the two groups. Results: The HAMD score and NPRS score in the observation group were lower than those in the control group (P <0.05). The total effective rate in the observation group was higher than that in the control group (P <0.05). The pain relieving time and pain disappearing time in the observation group were better than those in the control group, the difference was statistically significant (P <0.05). Conclusion: Sertraline combined with amitriptyline in the treatment of diabetic peripheral neuropathy has a good clinical efficacy, not only can effectively alleviate the patient’s depression, but also may relieve pain in patients.