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儿童肥胖,尤其中心性肥胖患儿其内脏脂肪分泌的脂肪因子(细胞因子)通过直接或间接机制损伤内皮细胞功能。脂肪细胞—血管调节轴直接调控内皮功能损伤的形成;脂肪因子导致胰岛素抵抗从而间接参与内皮细胞功能障碍。内皮功能损伤是动脉粥样硬化的前期阶段。予饮食疗法、运动疗法等可改善内皮细胞功能。
Adipogenic factors (cytokines) secreted by visceral fat in children with obesity, especially in central obese children, damage endothelial function through a direct or indirect mechanism. The adipocyte-vascular regulatory axis directly regulates the formation of endothelial dysfunction; adipokines lead to insulin resistance and thus indirectly to endothelial dysfunction. Endothelial dysfunction is an early stage of atherosclerosis. To diet therapy, exercise therapy can improve endothelial cell function.