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目的探讨POEMS综合片的临床特征,提高对POEMS综合征的诊疗认识。方法回顾性分析20例POEMS综合征患者的临床表现、辅助检查、治疗及预后。结果20例患者均有多发性神经病、水肿及皮肤色素沉着,淋巴结肿大者18例,内分泌改变者18例,异常球蛋白血症者16例。16例患者给予激素治疗,其中7例合用人血免疫球蛋白静滴。18例患者有不同程度的好转。结论POEMS综合征临床表现复杂多样,各主要症状出现顺序不一,涉及多系统,临床应注意鉴别诊断。
Objective To investigate the clinical features of POEMS syndrome and to improve the diagnosis and treatment of POEMS syndrome. Methods A retrospective analysis of 20 POEMS syndrome patients with clinical manifestations, laboratory examinations, treatment and prognosis. Results All the 20 patients had multiple neuropathies, edema and pigmentation, 18 cases of enlarged lymph nodes, 18 cases of endocrine changes and 16 cases of dysgalaurins. 16 patients were given hormone therapy, of which 7 cases of human immunoglobulin intravenous infusion. Eighteen patients had varying degrees of improvement. Conclusions POEMS syndrome complicated and diverse clinical manifestations, the main symptoms appear in different order, involving multiple systems, clinical should pay attention to differential diagnosis.