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复方铋合剂（Mixtura Bismuthi Composita）简称MBC，国外的类似制剂名为Tripotassiumdicitrato－bismuthal（简称TDB），对消化性溃疡的疗效已得到国内外肯定。但本剂所含胃蛋白酶对溃疡的愈合是否有不利影响尚无定论。据Stephens报道，由于铋的作用，制剂中所含胃蛋白酶已失去活性。Vantrappen认为服用TDR后，制剂中的铋在胃内与胃蛋白酶形式鳌合物，使胃蛋白酶灭活。本文目的在于进一步阐明我院自制的MBC制剂中的胃蛋白酶有无活性；以及服用本剂后是否能使胃内的胃蛋白酶灭活。
Mixtura Bismuthi Composita is abbreviated as MBC, and a similar preparation abroad is called Tripotassiumdicitrato-bismuthal (referred to as TDB). The curative effect on peptic ulcer has been affirmed at home and abroad. However, whether this agent contains pepsin has an adverse effect on the healing of ulcers is inconclusive. Stephens reports that due to the bismuth effect, the pepsin contained in the formulation has lost its activity. Vantrappen believes that after taking TDR, bismuth in the formulation is chelated with pepsin in the stomach to inactivate pepsin. The aim of this paper is to further elucidate the activity of pepsin in MBC preparations made in our hospital and whether pepsin in the stomach can be inactivated after taking this preparation.