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聚ＡＤＰ核糖多聚酶 (ＰＡＲＰ)是一种高度保守的核酶 ,参与ＤＮＡ损伤的修复。细胞凋亡早期ＰＡＲＰ被ｃａｓｐａｓｅ 3特异降解成 89与 2 4ｋＤａ两个片段 ,是细胞凋亡的一种标志。另一种标志是核酸内切酶催化ＤＮＡ片段化。本研究的目的是揭示细胞凋亡中细胞周期时相的特异
Poly ADP ribose polymerase (PARP) is a highly conserved ribozyme involved in DNA damage repair. In the early stage of apoptosis, PARP is specifically degraded by caspase 3 into 89 and 24 kDa fragments, which is a sign of apoptosis. Another hallmark is endonuclease catalyzed DNA fragmentation. The purpose of this study is to reveal the cell cycle phase specificity in apoptosis