男患.48岁.因慢性胃炎急性发作,肌注灭吐灵20mg,15分钟后,患者突然双目上视,全身不自主的阵挛伴意识丧失,尿失禁,呼吸不规则,血压130/90,面色苍白,唇绀,心肺肝脾无异常.经针灸,肌注安定,吸氧后,惊厥停止,神清,症状缓解.追溯患者二年前曾口服灭吐灵5mg 后,出现四肢短暂性、阵发性阵挛伴—过性意识障碍,停药后症状自行缓解.本例无其它诱因.二次口服灭吐灵出现相同症状,故诊断为灭吐灵所致的惊厥可 Male suffering .48 years old .Acute exacerbation of chronic gastritis, intramuscular metronidazole 20mg, 15 minutes later, the patient suddenly eyesight, involuntary clonic involuntary loss of consciousness, incontinence, irregular breathing, blood pressure 130 / 90, pale, cyanosis, heart and lung and liver and spleen are normal .Acupuncture and moxibustion, intramuscular stability, oxygen, the convulsions stopped, Shen Qing, symptoms relieved .Two years ago, patients with oral methotrexat oral oral emergence of limbs short Sexual, paroxysmal clonoconjunctival - transient disturbance of consciousness, withdrawal symptoms relieve themselves .This case no other incentive .Two oral metoclopramide appear the same symptoms, it is diagnosed as methotrexate-induced convulsion can be