异染性白质脑病(MLD)又称脑硫脂沉积病或芳基硫酸酯酶A(ASA)缺乏症。本病少见,现报告1例。女患,20岁,以嗜睡、反应迟钝、左侧上下肢活动无力20天入院。20天前无任何诱因出现嗜睡,对周围事情反应淡漠,继之左侧上、下肢活动无力,走路不稳。无发热。近2年曾反复发病3次,均在20余天后自行缓解。父母非近亲结婚,出生及生长发育史无特殊记 Metabolic leukoencephalopathy (MLD), also known as cerebral thrombosis or arylsulfatase A (ASA) deficiency. The rare disease, is reported in 1 case. Female, 20 years old, with drowsiness, unresponsiveness, left upper limb weakness 20 days admitted to hospital. 20 days ago without any incentive to lethargy, indifference to the surrounding things, followed by the left, lower limb weakness, walking instability. No fever. Nearly 2 years has repeatedly onset 3 times, all in more than 20 days to ease themselves. Parents of non-relatives marry, birth and growth and development history no special note