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７６例局部中、晚期初治鼻咽癌患者，放疗前被随机分成动脉灌注化疗（ＩＡＣＴ）和全身化疗（ＳＣＴ）两组，接受相同的联合方案（顺氯氨铂、５－氟脲嘧啶、平阳霉素和烟酰胺）治疗，观察两组的白细胞介素２活性（ＩＬ－２）和白细胞介素２受体（ＩＬ－２Ｒ）反应性的变化。结果表明；两组化疗前后各自的ＩＬ－２活性并无下降（Ｐ＞０．０５），而ＩＬ－２Ｒ反应性均有提高（Ｐ＜０．０５），两组相比，ＩＡＣＴ组的ＩＬ－２Ｒ改善又较ＳＣＴ组明显（Ｐ＜０．０５）。认为诱导化疗通过改善ＩＬ－２诱导的细胞免疫功能，可能是远期生存率得以提高的原因之一，并就诱导化疗方案的设计进行讨论。
76 patients with locally advanced nasopharyngeal carcinoma were randomly divided into two groups: IACT and SCT before radiotherapy. The same combined regimens (cisplatin, 5-fluorouracil, Pingyangmycin and niacinamide), and observed the changes of IL-2 and IL-2R reactivity in both groups. The results showed that IL-2 activity was not decreased (P> 0.05), but IL-2R reactivity was increased in both groups before and after chemotherapy (P <0.05) -2R improvement than SCT group was significantly (P <0.05). It is concluded that induction of chemotherapy may be one of the reasons for the long-term survival by improving IL-2-induced cellular immune function and discuss the design of induction chemotherapy regimen.