疟疾与艾滋病、结核为全球危害最严重的三大传染性疾病。蚊子作为疟疾传播过程中惟一的媒介生物,是疟原虫发育史中最薄弱的环节。大规模使用化学杀虫剂是过去几十年来控制疟疾的主要策略,但药物的反复使用、人口增长、卫生设施的缺乏等诸多因素,导致了蚊媒及疟原虫抗药性的产生 Malaria and AIDS, tuberculosis is the world’s three most catastrophic infectious diseases. As the only vector organism in the transmission of malaria, mosquitoes are the weakest link in the history of Plasmodium development. Large-scale use of chemical pesticides is the main strategy for malaria control in the past decades. However, many factors such as repeated drug use, population growth and lack of sanitation have led to the development of mosquito vectors and resistance to malaria parasites