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目的 :探讨残胃癌中nm2 3、p53、C erbB 2癌基因产物的表达与临床病理特点的关系。方法 :应用免疫组织化学S P法检测52例残胃癌中nm2 3、p53、C erbB 2癌基因产物的表达。结果 :52例残胃癌中 ,nm2 3阳性率 65 4% ,p53阳性率 2 5 % ,C erbB 2阳性率40 4%。三者的阳性表达水平与肿瘤的病理组织学分级差异显著。结论 :nm、p53、C erbB 2在残胃癌中的表达与肿瘤组织学分级有关 ,三者均可作为判断肿瘤恶性度的客观指标。残胃癌中C erbB 2、p53过表达nm2 3低表达是其易于浸润和转移的原因之一。C erbB 2和p53过表达提示残胃癌分化较低
Objective: To investigate the relationship between the expression of nm23, p53 and C erbB 2 oncogene products and clinicopathological features in gastric stump cancer. Methods: The expressions of nm23, p53 and C erbB 2 oncogene products in 52 cases with gastric remnant gastric cancer were detected by immunohistochemical SP method. Results: Of the 52 cases with gastric residual carcinoma, the positive rate of nm23 was 65.4%, the positive rate of p53 was 25% and the positive rate of C erbB2 was 40.4%. The positive expression levels of the three tumor histological grading significantly different. Conclusion: The expressions of nm, p53 and C erbB 2 in gastric cancinoma correlate with the histological grade of tumor. All three can be used as objective indicators to evaluate the malignancy of tumor. The expression of C erbB 2 and p53 overexpression nm 2 3 in gastric remnant carcinoma is one of the reasons that it is easy to infiltrate and metastasize. Overexpression of C erbB 2 and p53 suggests lower gastric cancer differentiation