碱性成纤维细胞生长因子是一种具有多种功能的促有丝分裂原 ,与肾小球疾病有密切关系。近年来研究证实它能够促进系膜细胞、肾间质成纤维细胞增殖及ECM产生 ,能引起足突细胞破坏 ,与TGF β1有协同作用。本文综述了它的理化性质、功能及其在肾小球硬化、肾脏疾病进展中所起的作用。 Basic fibroblast growth factor is a multi-function mitogen, and glomerular diseases are closely related. In recent years, studies have shown that it can promote mesangial cells, interstitial fibroblast proliferation and ECM production, can cause foot process cell destruction, and synergistic effect with TGF β1. This article reviews its physico-chemical properties, its function and its role in the progression of glomerulosclerosis and renal disease.