一、作用机制目前,钙拮抗剂有20余种,分为选择性与非选择性两大类,见表1。据晚近报道,钙拮抗剂的作用机制主要是:①选择性地阻滞心肌细胞和血管平滑肌细胞(包括支气管、胃肠道及泌尿生殖道平滑肌)Ca~(2+)跨膜慢内向离子流并阻滞Ca~(2+)自肌浆网进入肌浆,从而阻断 First, the mechanism of action Currently, there are more than 20 kinds of calcium antagonists, divided into two categories of selective and non-selective, see Table 1. According to a recent report, the main mechanism of action of calcium antagonists: ① selective blocking of myocardial cells and vascular smooth muscle cells (including bronchial, gastrointestinal and genitourinary smooth muscle) Ca ~ (2 +) transmembrane slow inward ion flux And block Ca ~ (2+) from sarcoplasmic reticulum into the sarcoplasm, thus blocking