9,22号染色体易位所产生的 Ph 染色体是第一个被发现与肿瘤有关的异常染色体。慢性粒细胞白血病(CML)患者绝大多数有此种特异性染色体改变.本文所检测的 CML 患者均含有 Ph 和9q~+染色体。9,22号染色体易位过程中将9号染色体上 ab1癌基因移位到22号染色体的 bcr 区内,ab1癌基因顺序和22号染色体基因顺序相融合,产生新的9kb 大小 ab1 The Ph chromosome produced by chromosome 9 and 22 translocations was the first abnormal chromosome that was found to be associated with tumors. The majority of patients with chronic myeloid leukemia (CML) have this specific chromosomal alteration, and all CML patients tested here contain Ph and 9q ~ + chromosomes. During translocation of chromosome 9 and 22, the abl oncogene on chromosome 9 was translocated to the bcr region on chromosome 22, and the sequence of abl oncogene and chromosome 22 was fused to generate a new 9 kb size abl