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Background There are some conflicting evidences showing that matal exposure to antibiotics may increase the risk of infant eczema.The present study aims to estimate the effect of prenatal antibiotics administration on infant eczema.Methods According to the established inclusion criteria,eligible observational studies were collected by comprehensive database search.The qualities of the included studies were assessed using the Newcastle-Ottawa Scale.Effect sizes that were adjusted by multivariable models were extracted and combined.Publication bias was evaluated by visual inspection of funnel plot.Results A total of seven observational studies were included.The qualities of the included studies were at moderate or high level.Prenatal antibiotics use was positively associated with eczema before one year of age [odds ratio (OR) =1.93,95％ confidence interval (CI) 1.35-2.76].In addition,antibiotics exposure in utero was likely to be related to eczema after one year of age (OR 1.21,95％ CI 0.98-1.49).The exposure to antibiotics during third trimester was not associated with infant eczema (OR0.97,95％ CI 0.86-1.09).Conclusions Matal exposure to antibiotics is associated with eczema by one-year age and may have a prolonged effect on eczema after 1-year age.The influence of timing of antibiotics exposure during pregnancy needs more studies to clarify.