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目的:探讨HA或DA联合治疗慢性粒细胞白血病的效果。方法:HA或DA联合治疗慢性粒细胞白血病,HA方案:三尖杉酯碱(H)(4～6)mg/d,阿糖胞苷(A)200mg/d,加入液体静滴,第1～7天。DA方案:柔红霉素(D)(40～60)mg/d,加入液体静滴,第1～3天,阿糖胞苷(A)剂量用法同上,均为每7天1个疗程。2个疗程间歇7～14天。结果:完全缓解(CR)56例(66.7%),其中HA方案1个疗程达CR24例,2个疗程达CR10例,HA和DA方案交替3个疗程达CR22例;部分缓解(PR)22例,(26.2%);总有效率92.9%;无效6例(7.1%)。26例做了染色体检查,发现10例Ph1染色体阳性,其中12例达CR,而CR患者有4例转阴。结论:HA或DA联合治疗效果明显。
Objective: To investigate the effect of combined HA or DA treatment on chronic myeloid leukemia. Methods: HA or DA combined treatment of chronic myeloid leukemia, HA program: harringtonine (H) (4 ~ 6) mg / d, cytarabine (A) 200mg / d, adding liquid intravenous infusion, the first ~ 7 days. DA program: daunorubicin (D) (40 ~ 60) mg / d, adding liquid intravenous drip, the 1st to 3 days, cytarabine (A) dose usage ibid. 2 courses intermittent 7 to 14 days. RESULTS: 56 patients (66.7%) had complete remission (CR). Among them, 24 courses of CR were treated in one regimen of HA regimen, 10 cases of CR were treated in two regimens, 22 cases of CR and CR were alternated in HA and DA regimens, 22 cases of partial remission , (26.2%); the total effective rate was 92.9%; 6 cases were ineffective (7.1%). Twenty-six patients had a chromosomal test and found 10 Ph1 chromosomes positive, 12 of whom reached CR, while 4 of CR patients turned negative. Conclusion: HA or DA combination therapy has obvious effect.