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目的观察妈富隆联合归肾丸治疗围绝经期功能失调性子宫出血(DUB)的临床效果。方法选取医院诊断为DUB的患者70例为研究对象,在诊断性刮宫后第5天开始服用妈富隆,每天2片,止血3 d后降至每天1片,同时服用归肾丸,每天1剂,连服21 d为1个周期,停药撤退性出血第3天开始下一周期,每天服用妈富隆1片,连服21 d,同时服用归肾丸。比较临床症状(月经不调)、治疗前后血清性激素水平(FSH、LH、E2)、子宫内膜厚度变化。结果 DUB患者治疗前月经不调为70例,治疗后月经不调为10例,差异有统计学意义(P<0.05)。治疗后患者LH、FSH、E2浓度较治疗前明显下降(P<0.05或P<0.01);子宫内膜较治疗前明显变薄(P<0.05)。结论妈富隆联合归肾丸治疗围绝经期DUB能有效改善子宫内膜厚度,有效改善症状,使血清性激素水平下降。
Objective To observe the clinical effect of Marvelon combined with Guishen Wan in treating peri-menopausal dysfunctional uterine bleeding (DUB). Methods Seventy patients diagnosed as DUB in our hospital were enrolled in this study. Marvelon was started on the fifth day after the diagnosis of curettage. Two tablets per day were given, and the dosage was reduced to one tablet a day after 3 days. One pill per day , And even served 21 d for a cycle withdrawal withdrawal bleeding the first 3 days to start the next cycle, daily taking Marvelon 1, even for 21 d, while taking Guishen pill. Compare clinical symptoms (irregular menstruation), serum hormone levels (FSH, LH, E2) before and after treatment, endometrial thickness changes. Results DUB patients before treatment, irregular menstruation was 70 cases, 10 cases of irregular menstruation after treatment, the difference was statistically significant (P <0.05). After treatment, the levels of LH, FSH and E2 in patients were significantly lower than those before treatment (P <0.05 or P <0.01). The endometrium was significantly thinner than that before treatment (P <0.05). Conclusion Marvelon combined with Guishen Pill can effectively improve the thickness of endometrium, improve the symptoms effectively and decrease the level of serum sex hormone.