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作者应用特殊的放射免疫方法测定23例未经治疗的成年发病的糖尿病患者和23例正常对照者的空腹血浆高血糖素含量,发现在糖尿病患者,虽然他们的血糖及胰岛素浓度增高,空腹高血糖素症是十分显著的。对10名糖尿病人和10名正常对照者进行了口服葡萄糖耐量试验,并进行了血糖、胰岛素和高血糖素浓度变化的研究。口服葡萄糖后,在糖尿病人高血糖素浓度明显升高而正常对照者是降低的。对这差异,曾有各种不同的解释。Müller等提出,在未经治疗的成年发病的糖尿病人中,血中高血糖素过多,可能由于胰岛素不足、内生胰岛素作用减弱或在α细胞中碳水化合物的某些方面代谢异常。
The authors used a specific radioimmunoassay method to measure fasting plasma glucagon levels in 23 untreated, adult-onset diabetic patients and 23 normal controls and found that in diabetic patients, although their blood glucose and insulin concentrations were elevated, fasting hyperglycemia Symptoms are very significant. Oral glucose tolerance tests were performed on 10 diabetics and 10 normal controls, and changes in blood glucose, insulin, and glucagon concentrations were studied. After oral glucose, the concentration of glucagon in diabetic patients was significantly higher than that in the normal controls. There have been various interpretations of this difference. Müller et al. Suggest that hyperglycemia in the blood of untreated adult patients with diabetes may be due to impaired insulin, diminished endogenous insulin or metabolic abnormalities in certain aspects of carbohydrates in alpha cells.