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目的:观察纳洛酮对脑出血的临床效果。方法:将48例脑出血患者随机分为2组:常规组24例采用降低颅内压、控制血压等对症治疗;纳洛酮组24例在常规治疗基础上加用纳洛酮0.4mg,每天2次,静脉滴注。2组疗程均为14d,观察评价脑出血治疗有效率,神经功能恢复情况。结果:纳洛酮组总有效率87.5%,对照组总有效率75.0%,两组治疗后神经功能缺损程度评分,纳洛酮组神经功能缺损程度评分均高于对照组(P<0.05),提示神经功能恢复优于对照组。结论:纳洛酮治疗急性脑出血可明显减轻脑水肿提高治疗有效率、促进神经功能恢复。
Objective: To observe the clinical effect of naloxone on intracerebral hemorrhage. Methods: Forty-eight patients with cerebral hemorrhage were randomly divided into two groups: 24 cases in the conventional group were treated by intracranial pressure reduction and blood pressure control; 24 cases in the naloxone group were treated with naloxone 0.4 mg on a daily basis 2 times, intravenous drip. Two groups of treatment were 14d, observation and evaluation of the effectiveness of treatment of cerebral hemorrhage, neurological recovery. Results: The total effective rate was 87.5% in the naloxone group and 75.0% in the control group. The scores of neurological deficits and neurological deficits in the naloxone group were significantly higher than those in the control group (P <0.05) Prompted neurological recovery superior to the control group. Conclusion: Naloxone treatment of acute intracerebral hemorrhage can significantly reduce cerebral edema and improve the efficiency of treatment, and promote neurological recovery.