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目的:探讨研究社区老年单纯收缩性高血压(ISH)的药物治疗。方法:选取老年单纯收缩性高血压120例,将其分成观察组和对照组,两组各60例,给予对照组服用硝苯地平缓释片,每12小时20mg,需连用四周。观察组的方法同对照组,再加用双氢克尿塞片,一次25mg,每天一次,也连服四周。对两组的血糖、血脂、血黏、血压等情况变化进行观察。结果:两组在治疗前后,患者的血糖、血脂、血黏度没有显著变化。治疗后,两组血压比较,其差异具有统计学意义(P<005)。结论:CCB类药物与小剂量利尿剂的联合使用,对老年单纯收缩性高血压患者治疗效果比单用CCB类药物要好,且不良反应少和安全。
Objective: To investigate the drug treatment of elder isolated systolic hypertension (ISH) in the community. Methods: A total of 120 elderly patients with isolated systolic hypertension were selected and divided into observation group and control group. 60 patients in each group and nifedipine sustained-release tablets in control group were administered with 20 mg every 12 hours for four weeks. The observation group method with the control group, plus two hydrochlorothiazide tablets, once 25mg, once daily, and even served for four weeks. The two groups of blood glucose, blood lipids, blood viscosity, blood pressure and other changes were observed. Results: Before and after treatment, there was no significant change in blood glucose, blood lipid and blood viscosity in both groups. After treatment, the two groups of blood pressure, the difference was statistically significant (P <005). Conclusion: The combined use of CCB and low-dose diuretics is better than CCB alone in treating elderly patients with isolated systolic hypertension with less adverse reactions and safety.