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目的:观察四妙勇安汤合犀黄丸加减联合西药治疗溃疡型胃癌的临床疗效及对患者人异粘蛋白(MTDH)表达的影响。方法:将溃疡型胃癌患者76例随机分为对照组与观察组,各38例。对照组采用常规西药治疗,观察组在对照组的基础上加用四妙勇安汤合犀黄丸加减方治疗,观察患者症状及体征的改善情况,比较2组治疗效果,并检测治疗前后患者MTDH蛋白表达水平。结果:总有效率观察组为89.47%,对照组为63.16%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者胃脘痛、五心烦热、痞满、便干色黑症状积分均较治疗前降低(P<0.05),且观察组上述各项积分下降较对照组更显著(P<0.05)。治疗后MTDH过度表达率观察组为13.16%,对照组为36.84%,2组比较,差异有统计学意义(P<0.05)。2组治疗期间均未见严重不良反应。结论:采用中药四妙勇安汤合犀黄丸加减联合西药常规方案治疗溃疡型胃癌,可提高临床疗效,降低MTDH过度表达,安全性较高。
Objective: To observe the clinical curative effect of Simiao Yongan Decoction and Rhizoma Huizhu Pills combined with western medicine on gastric ulcer gastric cancer and its effect on the expression of human mucin (MTDH). Methods: 76 patients with ulcerative gastric cancer were randomly divided into control group and observation group, 38 cases in each. The control group was treated with conventional western medicine. The observation group was treated with Simiao Yongan Decoction and Rhubarb Huangwan Decoction on the basis of the control group, and the improvement of the symptoms and signs of the patients were observed. The therapeutic effects were compared between the two groups before and after treatment Patients MTDH protein expression levels. Results: The total effective rate was 89.47% in the observation group and 63.16% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the scores of stomachache, five upset hot, fullness of the liver, dry-darkness symptom in both groups were significantly lower than those before treatment (P <0.05), and the scores in the observation group decreased more than those in the control group (P < 0.05). After treatment, the over-expression rate of MTDH was 13.16% in the observation group and 36.84% in the control group. There was significant difference between the two groups (P <0.05). No serious adverse reactions occurred in the two groups during the treatment. Conclusion: The Chinese medicine Simiao Yongan Decoction Rhizoma yellow pill plus conventional Western medicine regimen for the treatment of gastric ulcer can improve clinical efficacy, reduce MTDH overexpression, high safety.