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目的探讨小剂量A型肉毒毒素(BTX-A)多点注射治疗颜面部痉挛的临床疗效及安全性。方法回顾性分析BTX-A注射治疗颜面部痉挛患者的资料,评估疗效起止时间、症状缓解程度、不良反应发生率及其严重程度。结果 80例患者接受BTX-A注射治疗。平均起效时间(3.2±1.6)d,达高峰时间(7.2±2.2)d,疗效维持时间(19.6±6.1)周。达到完全缓解50例(62.5%)、明显缓解26例(32.5%)、部分缓解4例(5%)。14例(17.5%)患者出现轻度不良反应。结论小剂量BTX-A多点注射能够明显改善颜面部痉挛患者的症状,不良反应轻。
Objective To investigate the clinical efficacy and safety of multi-point injection of botulinum toxin A (BTX-A) in the treatment of facial spasm. Methods The data of patients with facial spasticity treated with BTX-A injection were retrospectively analyzed. The onset and ending time, the degree of symptom relief, the incidence of adverse reactions and their severity were evaluated. Results Eighty patients received BTX-A injections. The mean time to onset of action was (3.2 ± 1.6) d, peak time was (7.2 ± 2.2) d, and the effect maintenance time was (19.6 ± 6.1) weeks. Fifty patients (62.5%) achieved complete remission, 26 (32.5%) were relieved and 4 (5%) partially relieved. Fourteen patients (17.5%) had mild adverse reactions. Conclusion Small doses of BTX-A injection can significantly improve the symptoms of facial spasm patients with mild adverse reactions.