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目的观察川芎嗪治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将56例HIE患儿随机分为治疗组和对照组(各28例),并给予西医常规治疗;治疗组在常规治疗基础上给予川芎嗪注射液静脉滴注。疗程10天。结果治疗组总有效率为82.14%,对照组为64.29%,两者有显著性差异(P<0.05);两组治疗后血清总钙水平明显升高(P<0.05),血清酶活性降低(P<0.05),且治疗组各指标的改善优于对照组(P<0.05)。结论川芎嗪可提高新生儿缺氧缺血性脑病的临床疗效。
Objective To observe the clinical efficacy of ligustrazine in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Fifty-six children with HIE were randomly divided into treatment group and control group (28 cases each), and were given conventional western medicine. The treatment group was given intravenous infusion of ligustrazine injection on the basis of routine treatment. Treatment for 10 days. Results The total effective rate was 82.14% in the treatment group and 64.29% in the control group, with significant difference (P <0.05). After treatment, the total serum calcium level was significantly increased (P <0.05) and the serum enzyme activity was decreased P <0.05), and the treatment group improved better than the control group (P <0.05). Conclusion Tetramethylpyrazine can improve neonatal hypoxic ischemic encephalopathy clinical curative effect.