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目的：观察合并抑郁的急性冠脉综合征（ACS）患者在冠状动脉介入治疗（PCI）术后6个月后血清脂联素浓度的变化。方法对191例确诊为ACS并成功行PCI术治疗的患者按照汉密尔顿抑郁量表（HAMD）评分分为对照组（92例）和抑郁组（99例），术后采用正规冠心病二级预防治疗方案；6个月后，比较两组中血清脂联素浓度、汉密尔顿抑郁量表（HAMD）评分（24项）、血脂、左室舒张末径（LVEDD）和左室射血分数（LVEF）等指标及心绞痛症状。结果在PCI治疗6个月后抑郁组HAMD评分有所改善但无统计学意义（P＞0.05），血清脂联素浓度升高但明显低于对照组（P＜0.05），LVEDD和LVEF、血脂无明显差异，抑郁组心绞痛发作例数较多。结论ACS合并抑郁的患者PCI术后抑郁无显著改善，心绞痛发作较多，血清脂联素浓度升高但程度明显低于非抑郁患者。“,”Objective To investigate the serum adiponectin (APN) level in patients with acute coranary syndrome (ACS) and depression after percutaneous coronary intervention (PCI). Methods Based on the respective Hamilton depression rating scale (HAMD) scores, 181 patients with ACS were divided into 2 groups:control group (n=92) and depression group (n=99). Then they undwerwent PCI and 6-month coronary heart disease secondary prevention treatment. Before and 6 months after PCI peripheral blood samples were collected to test the levels of serum lipids (TC, TG, and LDL-C). ELISA was used to test APN level. Post-PCI angina pectoris symptoms were recorded. Ultrasonic cardiography was used to measure the left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF). Results The HAMD scores 6 months after PCI of the depression group was lower than that before PCI, however, not significantly (P>0.05). The serum APN levels of these 2 groups 6 months after PCI increased significantly (both P<0.05), and the APN level 6 months after PCI of the depression group was significantly lower than that of the control group (P<0.05). There were no significant differences in the value of lipids, LVEDD, and LVEF between the two groups. Conclusion The symptom of depression cannot be significantly improved after successful PCI in the ACS patients with depression. Depression affects the effeciency of PCI. Treatment of depression improves the curative effect for ACS.