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运用免疫组织化学技术对51例纤维支气管镜咬检组织中的角蛋白（KER）及癌胚抗原（CEA）进行检测，并设5例正常支气管粘膜肺组织作对照。结果正常支气管粘膜肺组织均呈CEA阴性，而癌组织的阳性率为62％；各型肺癌的可疑组与确诊组的阳性率及染色强度均无差异；鳞状细胞癌（鳞癌）KER染色的阳性率及染色强度均与腺癌有显著差异；小细胞癌KER染色阳性率为90％。作者认为在纤支镜咬检组织的诊断中CEA染色可用于肿瘤的定性诊断；而KER检测对鳞癌与腺癌的鉴别有一定帮助；小细胞癌KER染色的高阳性率支持其与其他非小细胞癌共同起源于干细胞的说法。
Immunohistochemistry was used to detect keratin (KER) and carcinoembryonic antigen (CEA) in 51 patients with fiberoptic bronchoscopy. Five normal bronchial mucosal lung tissues were used as controls. Results The normal lung tissues of bronchial mucosa were negative with CEA, and the positive rate of cancer tissues was 62%. There was no difference in the positive rate and staining intensity between the suspicious group and the confirmed group; the squamous cell carcinoma (squamous cell carcinoma) KER staining The positive rate and staining intensity were significantly different from those of adenocarcinoma; the positive rate of KER staining in small cell carcinoma was 90%. The authors believe that CEA staining can be used for the qualitative diagnosis of cancer in the diagnosis of bronchoscopy bite tissue; KER detection is helpful in the identification of squamous cell carcinoma and adenocarcinoma; the high positive rate of KER staining in small cell carcinoma supports it and other non- Small cell carcinomas commonly originate from stem cells.