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为探讨益气活血剂治疗肾病综合征的作用机理 ,采用盐酸阿霉素成功复制出大鼠肾病模型 ,随机分为 4组 ,每组 10只 ,分别为正常对照组、模型对照组、强的松治疗组、强的松加益气活血剂治疗组。用药8周后 ,选取血液流变学、血清白蛋白、总蛋白、血液自由基 3项、组织自由基 3项作为观察指标。结果 :强的松加益气活血剂治疗组与模型对照组比较 ,绝大部分指标有改善 (P <0 .0 5或P <0 .0 1) ;与强的松治疗组比较 ,血清白蛋白 (A)、超氧化物歧化酶 (SOD)及血液流变学指标均有显著性差异 (P <0 .0 5或P <0 .0 1)。结果表明 :大鼠肾病综合征模型血液呈高凝状态 ,抗氧化能力下降 ,氧自由基增加 ;益气活血剂有改善血液高凝状态及抗氧化的作用
To explore the mechanism of Yiqi Huoxue in the treatment of nephrotic syndrome, a rat model of nephropathy was successfully replicated using doxorubicin hydrochloride and randomly divided into 4 groups of 10 in each group: normal control group, model control group, and strong The pine treatment group, prednisone plus Yiqi Huoxue treatment group. After 8 weeks of treatment, hemorheology, serum albumin, total protein, blood free radicals, and three free radicals were selected as observation indicators. RESULTS: Compared with the model control group, the prednisone plus Yiqi Huoxue treatment group improved most indicators (P <0.05 or P <0.01); compared with the prednisone group, serum white Protein (A), superoxide dismutase (SOD) and hemorheology indexes were significantly different (P <0.05 or P <0.01). The results showed that the rat nephrotic syndrome model showed hypercoagulable state, decreased antioxidant capacity, and increased oxygen free radicals; Yiqi Huoxue had the effect of improving blood hypercoagulability and antioxidation.