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用幼猫双眼或单眼慢性阿托品化的方法 ,造成屈光不正或屈光参差的弱视动物模型 ,在整个视觉发育期 ,连续检测其条栅视力 (GA)和对比敏感度函数 (CSF) ,并与正常幼猫相比较。结果表明 :正常幼猫的GA 3 5周龄时为 1 4 8± 0 31c/d ,达到成年 (1 6周龄 )后为 3 67± 0 1 4c/d ,屈光不正组分别为 1 0 0± 0 2 5c/d和 2 1 5± 0 65c/d ,屈光参差组分别为 1 2 6± 0 30c/d和 2 0 5± 0 4 0c/d。在 1 6周龄屈光不正组或屈光参差组与正常组之间均有显著性差异 (t =4 839和 7 0 1 2 ,P均小于0 0 1 ) ,屈光不正组与屈光参差组之间却无显著性差异 (t=0 4 1 0 ,P >0 50 )。屈光不正组和屈光参差组猫CSF均低于正常 ,且以屈光参差组更明显。总之 ,人工模拟的屈光不正和屈光参差均造成幼猫GA和CSF的功能障碍 ,即弱视。两者所造成的视功能障碍无明显差异 ,可能意味着两者有相似的发病机制
Amblyopia models of anisometropic or anisometropic amblyopia caused by either binocular or monocular chronic atropine treatment were continuously examined for gaze visual acuity (GA) and contrast sensitivity function (CSF) throughout the visual development Compared with normal kittens. The results showed that the normal kittens had a mean age of 14 8 ± 0 31 c / day at GA 3, an average of 3 67 ± 0 1 4 c / d after reaching an age of 16 weeks, and an ametropic group of 10 0 ± 0 25c / d and 2 1 5 ± 0 65c / d, respectively. The anisometropia group was 126 ± 0 30c / d and 2 0 5 ± 0 4 0c / d, respectively. There was a significant difference between the 16-year-old refractive error group or the anisometropia group and the normal group (t = 4 839 and 7 0 1 2, P <0.01) There was no significant difference between the cohorts (t = 0 4 1 0, P> 0 50). The CSF CSF of patients with anisometropia and anisometropia were lower than normal and more obvious with anisometropia. In summary, artificial simulations of refractive errors and anisometropia contribute to the dysfunction of GA and CSF in kittens, ie, amblyopia. There was no significant difference in visual dysfunction between the two, which may imply that both have similar pathogenesis