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目的分析长方案及卵泡期超长方案两种降调节方式应用于体外受精-胚胎移植(IVF-ET)后的妊娠结局,探讨卵泡期超长方案的可行性和优越性。方法回顾性分析2014年1-11月在江西省妇幼保健院辅助生殖中心接受IVF-ET术治疗的3 399周期,根据降调节方式不同分为长方案组848个周期和超长方案组2 551个周期,分析两组妇女临床妊娠率、分娩率、平均孕周数及平均出生儿体重、出生儿早产率、低出生体重儿比率、性别比和新生儿出生缺陷等。结果超长方案组临床妊娠率66.16%和分娩率54.67%明显高于长方案组的59.27%和48.65%,差异有统计学意义(P<0.05);两组平均孕周及平均出生儿体重、出生儿早产率、低出生体重比率、性别比和新生儿出生缺陷率等差异无统计学意义(P>0.05)。结论卵泡期超长方案与长方案相比,未增加早产率及低出生体重儿的比率,未增加出生缺陷,但超长方案临床妊娠率和分娩率结局更优,是IVF术治疗方案的又一选择。
OBJECTIVE: To analyze the feasibility and superiority of two long-term regimen of long regimen and follicular-phase regimen in the pregnancy outcome after in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis of 3 399 cycles of IVF-ET treatment in the MCH center of Jiangxi MCH from January to November 2014 was divided into 848 cycles of long-term treatment and long-term treatment of 2 551 cycles A cycle, the clinical pregnancy rate, delivery rate, average gestational age and average birth weight, birth premature birth rate, low birth weight children ratio, sex ratio and neonatal birth defects were analyzed. Results The clinical pregnancy rate and delivery rate in long-term regimen group were 66.16% and 54.67%, respectively, which were significantly higher than those in long-term regimen group (59.27% and 48.65%, P <0.05) There was no significant difference in preterm birth rate, low birth weight rate, sex ratio and neonatal birth defect rate (P> 0.05). Conclusions Compared with the long-term regimen, the long-term follicular regimen did not increase the rate of preterm birth and low birth weight infants, and did not increase the birth defects. However, the clinical pregnancy rate and delivery rate of the extra-long-term regimen were better than those of the long regimen. A choice.