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多数药物经吸收,进入血液后能不同程度地与血浆蛋白进行可逆性结合,其中结合型药物失去活性,只有游离型药物才呈现药理活性。同时服用两种或两种以上的药物,如果它们都可与血浆蛋白的同一部位结合,则发生竞争现象,结合率高的药物可把结合率低的药物从血浆蛋白结合部位置换出来。这时,被置换出来的药物活性增强或引起中毒反应。一般来说,这一相互作用限于血浆蛋白结合率高、分布容积小及消除慢的药物。临床上,以下药物合用时应提高警
Most drugs by absorption, after entering the blood to varying degrees and plasma proteins for reversible binding, in which the combination of drug loss of activity, only the free-type drugs showed pharmacological activity. Taking two or more medications at the same time, if they both bind to the same site on the plasma protein, a competitive phenomenon occurs. The high binding rate drug displaces the low binding rate drug from the plasma protein binding site. At this moment, the activity of the drug being displaced is enhanced or the poisoning reaction is caused. In general, this interaction is limited to high plasma protein binding rate, small volume of distribution and elimination of slow drugs. Clinically, the following drugs should be combined to improve the police