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目的:分析CO2激光治疗早期声门型喉癌患者术后复发的相关因素。方法:回顾性分析134例超脉冲CO2激光治疗的早期声门型喉癌患者的临床资料,观察其复发与性别、年龄、病理分化程度、T分期、前联合受侵情况及甲杓肌受侵情况的关系。结果:高分化鳞状细胞癌复发率为11.83%,中分化鳞状细胞癌为18.42%,低分化鳞状细胞癌为33.33%,差异无统计学意义(P>0.05);T1a复发率为13.24%,T1b复发率为18.92%,T2复发率为23.08%,差异无统计学意义(P>0.05);前联合受侵者术后复发率为33.33%,未受侵者术后复发率为5.43%,差异有统计学意义(P<0.01);甲杓肌受侵者术后复发率为59.09%,未受侵者术后复发率为5.36%,差异有统计学意义(P<0.01)。单因素和多因素分析显示前联合及甲杓肌受侵是复发的相关因素。结论:前联合及甲杓肌受侵者术后复发率明显增高;肿瘤的切除应根据肿瘤的范围和深度,分别施行不同类型的切除。
OBJECTIVE: To analyze the related factors of postoperative recurrence of patients with early glottic laryngeal cancer treated with CO2 laser. Methods: The clinical data of 134 patients with early glottic laryngeal carcinoma treated with ultra-pulsed CO2 laser were retrospectively analyzed. The recurrence and gender, age, pathological differentiation, T stage, anterior invasion and the invasion of The relationship between the situation. Results: The recurrence rate of well-differentiated squamous cell carcinoma was 11.83%, moderate differentiated squamous cell carcinoma was 18.42%, poorly differentiated squamous cell carcinoma was 33.33%, the difference was not statistically significant (P> 0.05); T1a recurrence rate was 13.24 %, The recurrence rate of T1b was 18.92%, the recurrence rate of T2 was 23.08%, the difference was not statistically significant (P> 0.05). The recurrence rate of the anterior combined invasion was 33.33%, the recurrence rate of non-invaded persons was 5.43 %, Respectively. The difference was statistically significant (P <0.01). The recurrence rate was 59.09% in patients with thyroid muscle invasion and 5.36% in those without invasion. The difference was statistically significant (P <0.01). Univariate and multivariate analysis showed that the antecedent and the graded muscle were the related factors of recurrence. CONCLUSION: The recurrence rate of the anterior and the thyroid muscle invaders is significantly increased. The resection of the tumor should be performed according to the scope and depth of the tumor.